Applications :

Web
Firefox!
->and Adblock Plus to go with that
My Yahoo! (iGoogle isn’t quite as well done)
Answers.com
(web search either Yahoo! or Google)

E-Mail :
G-Mail
Thunderbird! (accessing G-Mail)
*(only for outlook) -> xobni (in case your wondering, inbox -> xobni)

Web Design :
Aptana Studio
A List Apart
Fireftp
XXAMP
Drupal

Operating Systems:
Mac OSX
Ubuntu
Windows
(there all good, with different strengths, and I use them all.
However, my primary computer is Win XP based with a virtual Ubuntu)

System Utilities :
7-Zip,
Yahoo! Widgets (Google desktop widgets are WAAAY too unstable)
Google Desktop (only for the search, it bogs down lesser computers, but it allows for Super Fast Accurate searching of EVERYTHING.)

IM clients {
Digsby | Skype }

Editors :
Paint.net (or something like enhanced paint)
Google Sketchup
Adobe Photoshop Elements
Adobe Premiere Elements
Inkscape (for SVG, or Illustratons)

Text Editor :
MS Word
Open Office
Dark Write (or somthing like that)

Remote Desktop {
Microsoft Built-in XP Pro | Tight VNC (for connecting to macs from windows) }

—->
That Should be about all, is there anything I missed, or anything you think shouldn’t be on here.
You can Google all the apps names for download or to use, but try to find legitimate sites (C-Net, the Author’s Site, SourceForge), or you can just ask for a link. – Iain